Pharmacological potential of natural flavonoid diosmin against n-nitrosodiethylamine induced hepatocellular carcinogenesis in wistar albino rats

Abstract

The present analysis attempts to scrutinize anticancer and medicinal perspective of polyphenol diosmin against chemically induced experimental hepatocarcinogenesis. Flavonoids are one of the common components in the human diet and main resource of this polyphenol is fruits, vegetables, and seeds. Flavonoids are widely present in the genus Citrus belonging to Rutaceae family. Hepatocellular carcinoma was induced through administration of 0.01% N-Nitrosodiethylamine through drinking water for 16 weeks. Hepatocarcinogenesis shows the alterations in the body, organs weight and also levels of nucleic acids (DNA & RNA), tumour marker enzymes (AST, ALT, ALP, LDH, γ-GT and 5’NT), xenobiotic enzymes (Phase I & II) and histopathological changes of the liver and kidney. These biochemical and morphological revolutionize may be due to pathogenesis of hepatocytes induced by NDEA and it was suppressed by the management with natural bioflavonoid diosmin (200 mg/kg/b.w/p.o) for 28 days. Due to curative property of diosmin, it preserves the biochemical enzymes at customary level and convalesce the structural damage induced by the chemical carcinogen.