Evaluation of the effect of alkaloids of Mitragyna ciliata on markers of immunity and some hematological parameters in rabbits

Abstract

Mitragyna ciliata (Rubiaceae) is a plant used in traditional medicine in the treatment of malaria in Côte d’Ivoire. The research for other properties in particular immunostimulatory, of this plant to strengthen malaria treatment is the cause of this study through the evaluation of effect of the total alkaloids on cell and humoral markers of immunity and some hematological parameters in rabbit. This investigation was carried out with 15 rabbits divided into five groups of three rabbits for each group. After treatment, blood samples were taken successively on the third day (D3), the seventh day (D7) and the fourteenth day (D14). The biological parameters such as lymphocytes, neutrophiles, albumin, globulins, red blood cells, platelets, hemoglobin and hematocrit were analyzed. Concerning this study, three major results were obtained. The first element is the fact that the alkaloids of M. ciliata not found to have immunostimulatory activity. The second element is the fact that within a homogeneous population of rabbits, the rate of biological parameters is not a fixed value. Finally, the results showed the absence of toxicity of these alkaloids against hematological parameters. Mitragyna ciliata remains an important medicinal plant made many pharmacological proprieties, due to the presence of its phytochemical compounds.