Aflatoxin B1 induced developmental nephrotoxicity in RIR egg

Abstract

The aim of this study was to investigate the developmental nephrotoxic potential of aflatoxin B1. Fertile RIR eggs were intoxicated with 5ng of aflatoxin at day ‘0’ incubation. Nephrotoxic activity of aflatoxin was assessed by biochemical parameters such as total protein, creatinine, acid phosphatase, N-acetylglucosaminidase, oxidative stress biomarkers and histopathology. In vivo administration of aflatoxin resulted in significant increases in ACP, creatinine and NAG levels and reduction in total protein content. The activity of catalase, glutathione peroxidase and reduced glutathione level decreased while the level of lipid peroxidation increased due to AFB1 intoxication. Histopathological lesion observed in kidney includes different degree of tubular necrosis, congestion, cellular hypertrophy and vacuolar degeneration. It was concluded that in vivo administered AFB1 adversely affected embryonic development of kidney and impaired its function.