Epigenetic, Main key of genes expression polymorphism, physiological dynamics and geographical worldwide diversity of Human Papilloma Virus (HPV), etiological agent of various affections: a retrospective observation

Abstract

Epigenetics may be defined as the study of all changes that are stably transmitted over many rounds of cell divisions, but that do not alter the nucleotide sequence (genetic code). Epigenetics encompasses many mechanisms such as DNA methylation, histone modifications and RNA-mediated gene silencing. All these mechanisms may modify the dynamic of human Papilloma virus (HPV) according to a lot of others factors such as environmental factors responsible of worldwide genotypes functional differences. With the aim to prove this hypothesis, a study base on retrospective observations was carried. Preliminary observations have presented the study of HPV diversity by regarding epigenetics changes as an important issue factor for general therapy development. Others observations focused on geographical distribution have presented what can be the epigenetic rule on this distribution worldwide. At the end of our retrospective study, the evolutionary dynamic has been explored and has revealed that, the ability of the oncovirus to transform the tissue into malignancy, depend in large part of epigenetic modulations. It could be possible to express the hypothesis according to which any genetic, physiological modifications and tissues changes are first preceded by epigenetic changes.