Novel topological modeling of ‘log P’ value of few aromatic derivative compounds

Abstract

The present work, effort  have been made to model of lipophilicity term log p of the  set of aromatic compounds to identify the quantitative structural activity relationship between biological activity and structure of aromatic derivatives by using multiple regression analysis with various descriptor the best model is obtained and validated by some cross validation parameters. The results were discussed on the basis of maximum R² value which indicates the six parametric model is the most significant model for the biological activity log P.