Chemical composition and anti-inflammatory activity of Asteriscus graveolens essential oils from south-western Algeria

Abstract

The objective of this work is the study of the chemical compositions, the acute toxicity and the anti-inflammatory activity of the essential oils (EOs) of the leaves and flowers from Asteriscus graveolens, collected in the south-west of Algeria. The chemical composition of EOs was established by gas chromatography (GC) and gas chromatography / mass spectrometry (GC/MS). The acute toxicity was assessed using Lorke's approach in Animal Models. The anti-inflammatory test was performed using an animal model and determined by carrageenan induced paw oedema. Thirty-four compounds were identified, accounting for 98.7 and 99.25% of the total EOs of leaves and flowers respectively. The major chemical components characterizing the EOs were oxocyclonerolidol, cis-chrysanthenyl acetate and cis-acetoxychrysanthenyl acetate, but the percentage of each compound varied depending on the EOs. The results obtained from the anti-inflammatory test showed that the EOs have a very high anti-inflammatory power with a dose dependent effect.